Karl Friston is one of the most influential neuroscientists of our time, yet many therapists encounter his work only at a distance. Originator of the Free Energy Principle, his thinking offers a way of understanding how minds manage uncertainty, form symptoms and change through relationship. In this live online Legacy Interview, Karl Friston joins Mark Solms and Jeremy Holmes in conversation with Jane O’Rourke to explore how ideas such as prediction, safety and active inference can speak directly to everyday therapeutic work across modalities.